What is Epigenetics?
I was recently interviewed by Bailey Kirkpatrick of the website WhatIsEpigenetics.com and was pleased to see our conversation appear on her website.
Epigenetics, if you haven’t already heard me talk about it, is my specialty. It is a way for me to delve into each client’s unique DNA and create a health and wellness plan that is specifically tailored to their genetic makeup, in addition to their lifestyle and current health conditions.
One medical practitioner I know recently scoffed at the idea of epigenetics making much of a difference in our health and wellness. The reason he gave was that our genes “only” make up 30% of the health equation.
Only 30%. Really.
Would you be happy if you ordered a pizza and a third of it was gone? I don’t think so. I think 30% is a big number and am excited that we can have that big an impact on our health by gaining more knowledge about our genes.
So with that intro, please read this article on the importance of epigenetics for your health.
Using Epigenetic Clues and Nutrition for a Comprehensive View of Our Health
Many of us are familiar with the foods that damage our bodies – they slow our metabolism, might add a few pounds, and stiffen our arteries. But what if certain food items could help or harm us in a place we may never have considered – like our DNA?
A developing field called nutriepigenomics examines the connection between diet and chemical marks that can be attached to or removed from our DNA, thereby turning genes on or off. Many new studies suggest that certain foods or supplements may be able to adjust the expression of our genes, potentially influencing our health, for better or worse.
Interestingly, many health professionals are beginning to incorporate epigenetics into their practice with the goal of providing more targeted and individualized treatment plans for the future.
“Layering information such as diet, lifestyle, environmental factors, family history, symptoms, and diagnoses along with epigenetics can help guide someone to a state of optimized health,” said Kristy Hall, MS, RNCP, ROHP, a board certified functional nutritionist and founder of Living Well Nutrition who uses epigenetic testing, nutrition counseling, and a multifaceted approach to better provide for her clients.
Countless factors including diet, exercise, and environmental exposure are all elements of our lives that have been shown to play a role in switching genes “on” or “off” via epigenetics. By adjusting the lifestyle factors that we can control we have the potential to reduce disease risk and make a positive impact on our health.
Epigenetics and Diet
So, what exactly is epigenetics and how can these marks or tags affect gene expression? After all, we’ve likely been living by the deeply-rooted notion that “our genes are our destiny” and epigenetics surely shakes up this relatively recently upturned misconception.
Epigenetics is the study of heritable chemical marks on specific parts of DNA that adjust the expression of our genes without affecting the underlying genetic sequence – the string of A, C, T, G bases all of us are familiar with.
Essentially, chemical marks attached to or removed from our DNA can influence our phenotype without ever altering our genotype.
It’s thought that our lifestyle and exposure to environmental factors, particularly in early development and other sensitive periods, but also throughout the course of our lives, have an influence on health and our susceptibility to disease.1
DNA methylation, for instance, is a well-known epigenetic mechanism characterized by the attachment of a methyl group to DNA by an enzyme called DNA methyltransferase (DNMT), which stifles gene expression.
New research links the Western Diet to changing DNA methylation levels in mice, which could harm the development of offspring even before they’re born.2 Food items like plant flavones and have been connected to changes in DNA methylation across the whole genome and on particular genes.
Another popular epigenetic mechanism known as histone modification is when histone proteins and DNA, a complex known as chromatin, become condensed or relaxed as a result of added or removed chemical marks, such as methyl or acetyl groups, on histones.
Typically, the more open and relaxed the chromatin structure, the more available it is for transcription and therefore, the greater the gene expression. Tighter chromatin restricts the expression of genes.
When we eat, tiny molecules that are broken down from food including carbohydrates, proteins, fats, and vitamins, are transported throughout the body to be used as energy or as building blocks.
Of course, we know that consuming too much sugar or fat can lead to obesity and set us up for diseases like diabetes or heart disease, and epigenetics gives us some insight into a part of the underlying mechanisms related to diet, disease, and our health.
Nutriepigenomics and Our Health
“When dealing with chronic disease, information is key,” said Hall. “Health is like a giant puzzle and the more pieces of the puzzle you have, the clearer the picture of your health becomes. While epigenetics may be only one layer, it is a critical one.”
Marks on genes that shouldn’t be there, or marks that are removed when they should stay put, have been connected to devastating effects on our bodies, such as the growth of tumors, the development of diseases like obesity or cardiovascular disease, and inflammation.3 Interestingly, we may be able to manipulate the dietary bioactive compounds we consume in order to affect epigenetic alterations that have been shown to be involved in the pathogenesis of numerous diseases.4
We may be able to manipulate the dietary bioactive compounds we consume in order to affect epigenetic alterations.
More than 1 out of 3 U.S. adults are obese, which sets them up for multiple health disorders and increases their likelihood of an early death.5 Previous research has shown that there may even be an epigenetic switch that, once turned on, may set us up for obesity later in life.6 Furthermore, epigenetic marks which influence signaling pathways might help predict a person’s likelihood of developing Type 2 diabetes7 or play a role in an individual’s chances for developing addictive behaviors8.
By utilizing personalized services which are becoming increasingly popular, we may be able to better monitor our health and make the right choices to improve it. According to Kristy Hall at Living Well Nutrition, professional epigenetics and nutrition guidance could be offered to find balance through a wholesome understanding of one’s health.
“The epigenetic test we use provides a tremendous amount of data that is clinically useful in the hands of the well-trained practitioner,” she said. “It offers information about critical metabolic pathways in the body, all of which are fueled by micronutrients like vitamins and minerals.”
Epigenetic Influence of Foods and Supplements
Scientific research is demonstrating that nutrients in different foods and supplements we consume may be able to adjust or reverse epigenetic mechanisms. While more studies must be conducted, the collection of fascinating epigenetic evidence can be used to support better lifestyle choices which are oftentimes already recommended for their general health benefits.
“Of course, there are foundations of health that will benefit everyone such as staying hydrated with clean water, eating a whole foods diet, getting the right amount of movement throughout the day, and so on,” Hall explained. “When you’re ready to move beyond the basics, that’s when we bring in the science of epigenetics.”
Numerous foods and supplements used in many studies assessing mouse and human models lend support the notion that epigenetics is highly involved in adjusting epigenetic tags, affecting our health and susceptibility to disease.
Polyphenols, for example, which are found in foods such as fruits, vegetables, olives, and chocolate, have been shown to be effective in promoting resilience again stress and reducing depression. In one mouse study, researchers administered grape-derived polyphenols known as dihydrocaffeic acid (DHCA) and malvidin-3′-O-glucoside (Mal-gluc).9
The combination of these compounds were found to epigenetically reduce stress and depression by modulating inflammatory responses and synaptic plasticity in the brains of those with depression. Phytochemicals like these are of particular interest to the scientific and health community due to their strong antioxidant, anti-inflammatory, antimicrobial, and anti-tumorigenic activities that contribute to health and wellness.
“Inflammation is involved in every step of tumorigenesis so when trying to protect against the development of cancer, it is useful to examine inflammation in the body,” noted Hall, who takes a close look at possible causes of inflammation in her clients.
Biochemically, there are inflammatory compounds that are self-perpetuating known as hydroxyl radicals and peroxynitrites, she explained.
“Epigenetic variants associated with the SOD gene could lead to an abundance of superoxide which, in turn, could lead to inflammation. Superoxide is developed in the creation of energy, ATP, but is also developed in abundance during a process called NOS uncoupling. This leads to peroxynitrite, a very inflammatory compound.”
Hall emphasizes the importance of using epigenetic information to create a focused protocol to support healthy biochemistry. “By assessing variants in an individual’s SOD and catalase genes, for example, we can determine his or her propensity of developing these inflammatory compounds and try to reduce them,” she said.
Along with inflammation, DNA damage is crucial to our health. It’s linked to why we grow older and why we might develop certain diseases like cancer.
Blueberries are incredibly high in antioxidants and it’s thought that this “superfood” can epigenetically reduce DNA damage, thereby protecting humans against cancer and possibly even slow aging. Blueberry juice and vitamin C have been shown to be potential methylation inhibitors for the MTHFR gene and the DNMT1 gene in humans.10 According to recent research, antioxidants may exert their biological effect through epigenetic modulation of DNA methylation and potentially other epigenetic mechanisms.
In addition, air pollution has a negative impact on our health and can also adjust important chemical tags on our DNA. It’s been shown to alter tags on DNA that can increase our risk for neurodegenerative diseases. Exposure to particulate matter has been connected to stroke, Alzheimer’s disease, Parkinson’s disease, cognitive impairments and neurodevelopmental disorders.11
B vitamins have potential to epigenetically protect against harmful pollution, which we may come in contact with at different stages of our lives and in various locations around the world.12 Air pollution has been shown to disturb DNA methylation profiles, which could worsen inflammatory and oxidative responses. Supplementing with B vitamins has been demonstrated to be able to prevent these changes.
Getting the whole picture of a person in numerous facets of life including diet, lifestyle, and their epigenetic profile will help drive successful health choices and can inform appropriate individual lifestyle adjustments.
“I spend a great deal of time looking at the various layer’s on someone’s health in order to create a personalized, precise protocol to optimize their health at their current phase of life,” Hall said.
It’s true that we’re straying from the “one-size-fits-all” mentality of healthcare and beginning to focus on the individual now more than ever.
The Future of Epigenetics and Personalized Health
Learning more about what we eat and what impact it may have on our bodies, especially the potential epigenetic impact it may have on our DNA – the very “code of life” – is just one step on the path to better health.
When’s the last time you really thought about how the foods you eat positively or negatively affect your body, health, and wellbeing? We’re all familiar with the benefits of eating healthy and the consequences of a poor diet, but we likely overlook the underlying molecular processes that are at play.
With more research and an increasing amount of practitioners like Kristy Hall, MS, RNCP, ROHP utilizing epigenetic information that’s unique to the individual, we can begin to unravel the mysteries of what may be contributing to our ailments and what could be done to help improve our health with a much more comprehensive understanding.
It’s intriguing to follow the progress of epigenetic testing and the benefits that analyzing the epigenome can have on guiding proper health regimens. As we continue to learn more about the impact our lifestyle has on epigenetic marks and the personalized insight it offers to us, this important new information can help point us in the right direction for optimized health and wellbeing.
Have questions? Want to learn more about how your genes may be better supported using the science of epigenetics? Give me a call and let’s talk.
This article was originally published on WhatIsEpigenetics.com
- Kanherkar, R.R., Bhatia-Dey, N., Csoka, A.B. (2014). Epigenetics across the human lifespan. Frontiers in Cell and Developmental Biology, 2:49. doi: 10.3389/fcell.2014.00049. ↩
- Mukerjee et al. (2018). Perinatal Exposure to Western Diet Programs Autonomic Dysfunction in the Male Offspring. Cell Molecular Neurobiology, 38:233-242 ↩
- Eggar, G. et al. (2004). Epigenetics in human disease and prospects for epigenetic therapy. Nature, 429(6990):457-63. doi: 10.1038/nature02625 ↩
- Bacalini, M. et al. (2014). Present and future of anti-aging epigenetic diets. Mechanisms of Ageing and Development, 136-137:101-115. doi: 10.1016/j.mad.2013.12.006 ↩
- “Overweight & Obesity.” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 5 Mar. 2018, www.cdc.gov/obesity/data/adult.html ↩
- Dalgaard, K., Pospisilik, A., et al. (2016). Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell, 164(3): 353–364. ↩
- “Type 2 Diabetes Mellitus and Epigenetics.” What Is Epigenetics?, 28 Nov. 2017, www.whatisepigenetics.com/type-2-diabetes-mellitus-and-epigenetics/. ↩
- Flagel, S.B. et al. (2016). Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model. Proceedings of the National Academy of Sciences, 113(20):E2861-70. doi: 10.1073/pnas.1520491113 ↩
- Wang, J., Pasinetti, G.M., et al. (2018). Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nature Communications, 9(1). DOI: 10.1038/s41467-017-02794-5. ↩
- Kim, M., Na, H., Kasai, H., Kawai, K., Li, Y.-S., & Yang, M. (2017). Comparison of Blueberry (Vaccinium spp.) and Vitamin C via Antioxidative and Epigenetic Effects in Human. Journal of Cancer Prevention, 22(3), 174–181. ↩
- Wei H. et al. (2017). Role of oxidative stress and DNA hydroxymethylation in the neurotoxicity of fine particulate matter. Toxicology, 380:94-103. doi: 10.1016/j.tox.2017.01.017 ↩
- Zhong, J. et al. (2017). B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. PNAS, 114(13):3503-3508. ↩